CETYL TRANEXAMATE HCL (also known as TXC™) is an oil-soluble derivative of tranexamic acid that offers enhanced skin penetration and is considered highly effective for skin brightening, lighten age spot, to remove pigmentation after sun exposure, dark spots acne, inflammation and reducing hyperpigmentation. It is often used in combination with other brightening agents like alpha arbutin, vitamin C, and niacinamide for synergistic effects.
Cetyl tranexamate HCL inhibits the plasminogen pathways, as a result, inhibiting melanogenesis. It inhibits dendrite interaction with keratinocytes.
COSMETIC BENEFITS OF CETYL TRANEXAMATE HCL:
Cetyl tranexamate HCL is primarily used in high-end skincare products to achieve a more even and brighter skin tone. Its main benefits include:
Skin Lightening and Brightening: Cetyl tranexamate HCL effectively reduces dark spots, age spots, and overall skin discoloration.
Hyperpigmentation and Melasma: Cetyl tranexamate HCL helps fade challenging pigmentation issues, including post inflammatory hyperpigmentation and melasma.
Anti-Inflammatory Properties: Cetyl tranexamate HCL helps to visibly reduce skin redness and signs of inflammation associated with conditions like rosacea and acne.
UV Damage Prevention: Cetyl tranexamate TXC prevents UV-induced hyperpigmentation.
CETYL TRANEXAMATE HCL SPECIFICATIONS:
INCI: Cetyl Tranexamate Hydrochloride.
CAS NO: 913541-96-5.
Usage rate: 1-5%. Do not exceed 5%, as higher concentration usage can irritate the skin.
Purity: 98%
Solubility: It is oil-soluble meaning it can be incorporated into oil-based formulations. it also dissolves in glycols at 60⁰C-70⁰C not to exceed 80⁰C (e.g., propylene glycol, butylene glycol) but not soluble in glycerin and water. A key difference from regular, water-soluble tranexamic acid.
PLEASE NOTE DISSOLVED APPEARANCE: Cetyl tranexamate HCl is an oil-soluble, glycol soluble ingredient. While it is soluble in oils with the use of gentle heat (typically 60⁰C−80⁰C), the resulting mixture is generally opaque. The oil solution maintains a white or creamy appearance, it forms a solution that is cloudy or milky white, and not a clear transparent oil liquid solution. Thus, it is used for creams, lotions, and serum emulsions, but not for clear transparent oil solution. This opaque, cloudy or creamy appearance is due to the chemical structure of CTH, which, even when dispersed in oil, forms a molecular assembly that does not result in a clear, transparent solution like some other active ingredients.
Temperature sensitivity: It is important not to heat the mixture above 80°C, as the ingredient is temperature sensitive.
Enhanced Efficacy: Due to its lipophilic (fat-loving) nature, it penetrates the skin better and faster, with some sources claiming it can be up to 60 times more effective at skin lightening than plain tranexamic acid.
Appearance: It is typically found as a fine white to off-white powder.
Stability: It is stable within an optimal pH range of 5.5 to 7.0 and should not be heated above 80°C during formulation.



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